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Genetic polymorphisms are heritable changes in DNA sequences as consequence of single-nucleotide polymorphisms or stable point mutations that may partially alter enzyme activity, or large deletions in coding sequences resulting in a null phenotype 24,34
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This could be associated with the damage to cell component, basement membrane and epithelia by lipid peroxidation, protein denaturation and enzyme inactivation in vascular endothelial cells
Priming microglia for innate immune memory in the brain
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