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While retatrutide shows lower potency at human GLP-1 and glucagon receptors compared to natural ligands, it demonstrates higher potency at the GIP receptor by a factor of nearly 9x, and the combined effect is what drives the superior outcomes
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Jensen J, Lendorf A, Stimpel H, Frost J, Ibsen H, Rosenkilde P
In addition, lifestyles and eating habits of different regions and ethnic groups may also affect the efficacy of tirzepatide
Cagrilintides best data are combination data
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