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In one study, adjusted odds ratios for MASLD demonstrated a clear gradient: lowest in never smokers, higher in exclusive cigarette smokers, and highest among dual users, suggesting an additive or even synergistic effect of combined exposure [140]

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The suppression of each node significantly decreased HEXB transcription, while HIF1 overexpression or transfection of YAP-5SA plasmid in GBM cells significantly increased their HEXB expression (Fig