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We found that 19 metabolites were significantly increased by MTX, whereas 12 were decreased in response to the drug treatment ( Figure 1A and Supplementary Table 4 )

Regulatory role of metallothionein-1/2 on development of sex differences in a high-fat diet-induced obesity

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Arch Biochem Biophys 433:166175 Banerjee R, Zou CG (2005) Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein