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Effect of dietary restraint during and following pegylated recombinant leptin (PEG-OB) treatment of overweight men
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PMID 26110123
Appetite suppression was discovered as a secondary effect during Phase I trials when subjects reported reduced hunger and unintentional weight loss
A switch from white to brown fat increases energy expenditure in cancer-associated cachexia
The resulting Fenton reaction generates hydroxyl radicals, promoting extensive lipid peroxidation and damaging macromolecules such as proteins, lipids, and DNA, ultimately leading to neuronal death (192)
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