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The approval came after a five-year SELECT trial funded by Wegovys manufacturer, Novo Nordisk, found that a weekly dose of 2.4 milligrams (mg) of semaglutide may be effective at lowering the risk of morbidity from heart disease and stroke in people who are overweight or with obesity but do not have diabetes
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Indeed, data from STEP-HFpEF and STEP-HFpEF DM trials have shown a significant reduction in inflammatory markers such as CRP with semaglutide compared with placebo 45,46
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