Fungal pathogen recognition by the NLRP3 inflammasome
According to an April 15 survey by healthcare company Tebra, more than a third of users of glucagon-like peptide-1 (GLP-1) receptor agonists are currently microdosing Ozempic and similar prescriptions, primarily due to the potential side effects associated with the drugs
Improved HbA1c: GLP-1 drugs consistently reduce HbA1c an important long-term marker of diabetes control often by 11.5%, depending on the agent and dose
Animal and translational work hints at synergy between estrogen signaling and GLP-1 pathways, raising the possibility that fluctuating sex hormone states (menstrual cycle, menopause, exogenous hormones) may shape both efficacy and side-effect profiles (Vigil et al., 2022
The SUSTAIN-6 trial demonstrated that Ozempic reduces the risk of heart attack, stroke, and cardiovascular death in this population
However, when the glucose load exceeds the renal glucose threshold, as is the case in people with uncontrolled hyperglycemia, glucose begins to appear in the urine a clinical finding termed glucosuria