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[16] This increase in antioxidant enzyme expression is mediated through signal transduction pathways activated by the binding of melatonin to its receptors

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Assessing changes in either large cerebral artery cross-sectional area and CBF (MRI) or cerebral hemodynamics (MCAv) in response to a vasoactive stimuli, such as carbon dioxide (CO 2 ), forms the basis of cerebrovascular reactivity (Wang et al., 2023)