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The clearest visible improvements, measurable changes in skin laxity, firmness, and tone, typically come at the eight to twelve week mark

Presented for research literature review only Vamvakas S et al

Stress Management: Chronic stress keeps the body in a "fight or flight" state, which constricts blood vessels

However, in the AWARD 7 trial, a dedicated 52-week trial of dulaglutide in patients with diabetic kidney disease, stage 3-4, the decline with time was significantly reduced compared with insulin glargine [29]

Most patients notice improvements within 2-4 weeks, but if youre not seeing changes, we pivot the approach until we find what works