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SIRT3, a class III HDAC associated with longevity, deacetylates Forkhead box protein O3a (FOXO3a) and promotes transcription of antioxidant enzymes (e.g., manganese superoxide dismutase and catalase), thereby constraining mitochondrial ROS and preserving redox homeostasis [71, 72]
Esposito, K
While the specific mechanism may differ slightly between pregnancy-related and GLP-1-related nausea, the brainstem pathways targeted are substantially similar, which provides a reasonable pharmacological basis for using B6 alongside semaglutide
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