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Mol Psychiatry 30 , 31203128 (2025)

These medications mimic a naturally occurring hormone (GLP-1) that regulates appetite and blood sugar

Collectively, these findings demonstrate sustained Exe4 expression and secretion by the liver following a single in vivo genome editing at the mouse Alb locus using LNP-mediated HITI, with no discernible side effects

Nature 363:356358 Arnette D, Gibson TB, Lawrence MC, January B, Khoo S, McGlynn K, Vanderbilt CA, Cobb MH (2003) Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic cells

This is why they work when diet and exercise alone haven't they're not suppressing willpower, they're correcting the underlying biology

In diabetes, the signal may not work well, leading to high glucose