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The difference is in the research target

Vitamin B12 deficiency can also result from poor nutrition, cancer, HIV, during pregnancy, old age, due to alcoholism

Community sources report a 16-week subcutaneous ladder of 250 mcg daily for Weeks 1-4, 375 mcg daily for Weeks 5-8, and 500 mcg daily for Weeks 9-16, but this is reported research context, not a recommendation

doi: 10.1073/pnas.89.10.4678

The reasons: Receptor sensitivity: While GHK-Cu doesn't appear to cause receptor downregulation the way some peptides do, cycling is a general precaution to maintain responsiveness and avoid adaptations that might blunt benefits

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