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247 Mechanistically, it is unclear how GLP-1-based therapies exert beneficial effects on the cardiovascular system, but studies have suggested that this is achieved by direct (cardiovascular GLP-1R activation) and indirect (promotion of the incretin effect) mechanisms
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Pdx1, in particular, plays a critical role in the development of the pancreas and the function of cells by binding to regulatory elements and promoting the transcription of the insulin gene (Yang et al., 2012)
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Lambadiari et al., 2018
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