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In the Retatrutide diabetes trial, gastrointestinal adverse events appeared in roughly 35 percent of treated participants, the same family of effects seen across this drug class, and no severe low-blood-sugar episodes or deaths were reported

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All 22 participants had previously been treated with a GLP-1 therapy for durations ranging from approximately 5 months to 5 years, with a mean total body weight loss of 24% while on therapy and a mean body weight of 80 kg 3 kg (SEM) at the time of intervention

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Compounded Tirzepatide: The same active ingredient as Mounjaro and Zepbound