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This distal tubular condition is perceived as a low effective circulating volume stimulus, at the level of juxtaglomerular apparatus, which promotes the inhibition of adenosine production that is associated with a vasodilatory response of the afferent arteriole (33)
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The transdermal approach provides a continuous delivery of RTG with stable and steady plasma levels over 24 h with a single daily application and its doses ranging from 2 to 16 mg/day
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