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Interestingly, supplementation of metformin with 1.5 mg dulaglutide per week in the treatment of T2MD in obese patients with severe impairment of glycosylated hemoglobin A1c (HbA1c) was reported to bring lasting benefits in the control of glucose metabolism and body weight (173)

While these measures can delay the progression of CKD to end-stage renal disease (ESRD), effective therapeutic options remain limited, particularly interventions capable of reversing CKD progression

Liu Y, Mao H, Hu C, Tron T, Lin J, Wang J, Sun B (2020) Molecular docking studies and in vitro degradation of four aflatoxins (AFB1, AFB2, AFG1, and AFG2) by a recombinant laccase from Saccharomyces cerevisiae

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2j), and this was confirmed by reduced pyruvate-induced glucose production (Fig