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It functions as an electron carrier in cellular respiration and as a substrate for sirtuins (longevity proteins) and PARP enzymes (DNA repair proteins)

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2,3-BPG is the major phosphorylated intermediate in the erythrocyte, present at even higher concentrations than ATP (12 mmol/L) or inorganic phosphate (1 mmol/L)

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While the intricate interplay of some proteins highlights the complexity of mitochondria-lysosome interactions, the specific regulatory mechanisms of others remain poorly understood, emphasizing the need for further investigation