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Side effect profiles are broadly similar across the GLP-1 class, with gastrointestinal symptoms predominating

Eli Lilly says full data from its latest Phase 3 trial will be published in a peer-reviewed journal at a future date.

Additionally, there have been case reports and anecdotal evidence suggesting that GLP-1 drugs can negatively impact mood

Clinicians should maintain a high index of suspicion for gastroparesis when patients report vomiting undigested food many hours after meals, severe refractory nausea despite antiemetic therapy, or inability to maintain adequate oral intake

For results expectations, see semaglutide results week by week

In a phase II study of the long-acting GLP-1RA efpeglenatide (4 mg once weekly, 6 mg once weekly, 6 mg once every 2 weeks, and 8 mg once every 2 weeks), patients with obesity and without diabetes had statistically significant reductions in body weight compared with placebo after 20 weeks of treatment (differences in least squares means were 6.3 to 7.2 kg