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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

The rapid pace of GLP-1-driven weight loss amplifies this risk compared to traditional diet-alone approaches

6.4 Evaluation in advanced-stage plaque models Most preclinical studies focus on early lesion development, leaving advanced disease stages underexplored

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A substantial body of evidence has accumulated with respect to how GLP-1 and its analogs act to restore and maintain normal cellular functions