Semaglutide, meanwhile, interacts only with the GLP-1 receptor
Other recognised side effects include: Fatigue and dizziness Headache Injection site reactions (redness, itching) Increased heart rate (typically modest) Gallbladder problems , including gallstones and cholecystitis (risk increased with rapid weight loss) Hypoglycaemia (mainly when used alongside insulin or sulfonylureas in people with diabetes) Risk of dehydration and acute kidney injury with severe gastrointestinal symptoms Diabetic retinopathy complications in people with pre-existing retinopathy Rare but serious adverse effects include pancreatitis (inflammation of the pancreas), which requires immediate medical attention if severe abdominal pain develops
They should resolve on their own quickly, letting you get back to your routine without much downtime
Combined with diet and enough exercise, GLP-1 might be an effective approach to weight management
If immediate transition is not feasible, establish an appropriate monitoring plan while continuing shared decision-making
TRT supports muscle repair processes