Even with a research history dating back to the 1970s, DSIP has somewhat fallen out of the scientific literature in the past 20-30 years, and much about its health applications is subject to debate
Acknowledgements We would like to acknowledge the following funding sources: R01 CA196660, P50 CA121974, P01CA128814, the Melanoma Research Alliance, the Melanoma Research Foundation and the Hervey Family Foundation (to MB)
By engaging GLP-1 Rs across the gut-brain axis, these agents potentiate physiological satiety signals, slowing gastric emptying, suppressing hunger cues, and diminishing the hedonic appeal of calorie-dense foods
Also, these medications should be used with caution in individuals with a history of pancreatitis or thyroid C-cell tumors due to a potential increased risk associated with these conditions
The microarray and RNA-seq datasets analyzed in this study were obtained from the Gene Expression Omnibus (GEO, database
Tseng, N., Lambie, S