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Meal sequence The order in which you eat in a meal can also influence the stimulation of GLP-1 and post-meal insulin and blood sugar responses
however, semaglutide is known to show higher GI side effects compared to others 12
However, from clinical studies alone, it is difficult to know how much of the benefit is due to direct effects in the joint and how much may be explained by weight loss or broader metabolic changes. That is why we wanted to address a basic mechanistic question first: whether GLP-1 is actually present in the joint environment
JAMA - J Am Med Assoc 316(5):500508
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