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This suppresses both endogenous GH secretion and the responsiveness of GHS-R1a receptors to exogenous agonists like Ipamorelin

1 Beyond the weight-loss stress response, researchers have proposed several contributing mechanisms: Hormonal shifts , changes in insulin and insulin-like growth factor (IGF-1) signaling during rapid weight loss, may influence androgen activity and accelerate androgenetic alopecia in genetically predisposed patients

It adds another layer for researchers studying energy-balance and broader metabolic signalling

Here is what changed this week, what it means, what it does not mean, and what we tell patients in clinic when they ask