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So it takes us back in history, but there was a period between World War II and 1970s where there was a lot of motivation in the research community to do these grand randomized controlled trials of nutrition

When cholesterol was added, an increase in membrane stiffness was observed, but the stiffening extent decreased with increasing chain unsaturation, indicating the dominance of cholesterols stiffening effect over PUFA-induced softening [175]

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Efficacy of addition of the anti-inflammatory, IV glutathione to standard ketamine IV therapy in major depressive disorder. Psychiatry Research 337 (2024): 115949