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The lyophilized presentation helps support peptide stability during storage while providing laboratories with a convenient format for experimental preparation

Other mechanisms by which ISOF attenuates lung inflammation have been validated in a chronic obstructive pulmonary disease model, including activation of adenylyl cyclase and downregulation of T helper cell 17 (Th17)/interleukin-17A (IL-17A) and NF-B/NLRP3 (Xiao et al., 2021a

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As humans do not produce TMCA, we examined the levels of non-12-OH FXR-antagonistic BA species in humans, and found that the levels of non-12-OH FXR-antagonistic BAs (HDCA and UDCA-related species) were positively correlated with T3 levels in euthyroid human study participants (Fig

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