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In rodents exposed to IH, inflammasome activation was associated with neuronal apoptosis in the hippocampus, as well as poor performance on the contextual fear conditioning, spatial learning, and memory tests (Gong et al., Figure 2 3.2 Cardiovascular complications The development of cardiovascular complications in individuals with OSA may also be associated with inflammasome activation (Figure 2) (Kohler and Stradling, 4 The inflammasome and OSA therapeutics 4.1 CPAP The current first-line treatment for OSA is continuous positive airway pressure (CPAP)

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Thus, although both peptides ultimately target GH secretion, their receptor-specific interactions potentially engage different yet complementary intracellular signaling pathways within pituitary cells