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Sci Rep 13 , 10996 (2023)

Reported or proposed issue Drug or supplement interactions Evidence source Mechanism-based theory Known or theoretical

2.2.2 Heat stress adaptation of the spermatogenic microenvironment The spermatogenic microenvironment refers to the local cellular and structural niche formed by Sertoli cells, Leydig cells, germ cells, and the bloodtestis barrier, which provides the essential conditions for spermatogenesis, including nutrient support, hormonal signaling, and immune privilege, thereby supporting normal sperm development (Kastelic et al., 2018

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Moreover, the treated rats exhibited a faster re-epithelialization and increased collagen deposition