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[PubMed] [PMC] Cholico GN, Fling RR, Zacharewski NA, Fader KA, Nault R, Zacharewski TR (2021) Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic -oxidation
PMC 2441858
Subsequently, lysates were centrifuged at 12,000 rpm for 15 min at 4 C to obtain clear supernatants
Cytochrome P450 is responsible for phase I metabolism (e.g., oxidation, reduction, hydrolysis, and hydration) (Hodek et al., 2002), and phase II metabolism involves various conjugation reactions, including glucuronidation, sulfation, and methylation (Zhu et al., 2024a)
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