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They reported improved developmental potential up to the blastocyst stage with higher blastocyst formation rate and increased total cell count and activity when the oocytes were matured in culture media added with 0.10.5 mg/mL LC

Given the observed hydrogen-bonding interactions with Q726 and Y524 and considering the contribution of the P-clamp region to PDE10A selectivity, future optimization should prioritize (i) enhancing potency by incorporating structural constraints that properly orient key substituents to reinforce the Q726/Y524 hydrogen-bond network and (ii) modulating lipophilicity and polar surface area to achieve an optimal balance between CNS penetration and effective P-clamp engagement

doi: 10.1093/sleep/26.7.902 5 BrodMHjbjerreLAlolgaSLBeckJFWilkinsonLRasmussenMH

ArticlePubMed 73