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Pattern HED extrapolation ceiling Daily Dose ~650 mg/day Tablet Math (50 mg) 13 tablets/day included only to show the gap with vendor doses Frequency n/a Notes Allometric scaling from 100 mg/kg/day mouse dose to 80 kg human

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It was first identified in 1973 by biochemist Loren Pickart, who observed that plasma from younger donors caused older liver tissue to resume more youthful metabolic activity

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