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Notably, a propargyl group at P1 or alternatively an extended P1 side chain resulted both in very potent and fairly selective IRAP inhibitors, 45 (DG046) with IC50 values of 2 nM and 46 with a IC50 value of 4 nM (Figure 11)
Vitamin B12 is essential for healthy red blood cells and nerve function, and when levels are low, symptoms can build gradually and be easy to dismiss as stress, sleep, or a busy life
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