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Additionally, accumulation of cyanocobalamin metabolites may occur in severe renal impairment, though this is rarely clinically significant

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Cell culture studies demonstrate increased expression of synaptic proteins including PSD-95, synaptophysin, and synapsin following Dihexa treatment, confirming molecular mechanisms underlying the observed synaptogenic effects

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10.1046/j.1471-4159.1995.64051965.x J

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