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Markers of apoptosis, including elevated Bax and caspase-3 along with reduced Bcl-2, were significantly dysregulated in the STZ-induced diabetic group in this study, indicating enhanced pro-apoptotic signaling and mitochondrial dysfunction 55,56
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The mechanism appears to involve interaction with the endogenous opioid systemDSIP modulates enkephalin and beta-endorphin release, suggesting opioid-system cross-talk
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Intestinal obstruction : Rare cases of ileus/intestinal obstruction have been reported in postmarketing surveillance