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The first part of the study began by randomly dividing the test subjects in four groups including: wild type, APP/PS1, APP/PS1 + Dihexa administered at a dose of 1.44 mg/kg, and APP/PS1 + Dihexa administered at a dose of 2.88 mg/kg [1]
Importantly, a substantial number of patients had multiple reasons noted for stopping (21%), underscoring the complexity of real-world medication use and the challenges patients face when using these therapies
It is this breadth of documented laboratory activity that makes it particularly relevant across multiple research disciplines
Not every patient responds at the same pace
Efficacy of uridine monophosphate, acetyl-L-carnitine and alpha lipoic acid in the treatment of pain in chronic neuropathy and radiculopathy: a review of the literature and an observational pilot study on radiculopathy
Although oral therapy with the least toxic of these compounds, glutathione monoethyl ester, did raise erythrocyte and white blood cell glutathione levels in a few affected patients (W Rhead, unpublished results), it also provoked moderate gastrointestinal irritation resulting in vomiting and diarrhea, largely precluding oral therapy with this compound or other related molecules containing free sulfhydryls
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