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q , Percentage to baseline of insulin tolerance test in Fig
GLP-1 is rapidly cleaved by the widely expressed dipeptidyl-peptidase-IV (DPP-IV), which removes two N-terminal amino acids, resulting in GLP-1(9-36) with little glucoregulatory properties but with potential cardiovascular effects [18]
The key to effective weight loss is losing excess body fat, not overall body weight
The pivotal STEP 1 trial demonstrated that participants receiving semaglutide 2.4 mg achieved an average weight loss of 14.9% of initial body weight over 68 weeks, compared to 2.4% with placebo
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