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I see people arguing that because we have not seen a clear increase in aspiration events, there is no need to treat these patients differently
mechanisms are complex and individual responses vary
Voorhamme, D., & Yandell, C
GLP-1 RAs reduce major cardiovascular events by 14% through multiple mechanisms beyond glucose control, including anti-inflammatory effects and blood pressure reduction SELECT trial proved cardiovascular benefits extend to non-diabetic patients with obesity, showing 20% MACE reduction in those without diabetes Semaglutide, liraglutide, and dulaglutide demonstrate the strongest cardiovascular protection, with proven benefits in large outcome trials These agents provide specific benefits for heart failure with preserved ejection fraction and kidney protection, reducing albuminuria by 24% Current guidelines strongly recommend GLP-1 RAs for patients with established cardiovascular disease, regardless of diabetes status or HbA1c levels The evidence positions GLP-1 receptor agonists as fundamental cardiovascular medications rather than merely diabetes drugs with heart benefits
However, our local pharmacies report intermittent supplies from distributors, so prescribers are urged to ensure consistent local supplies prior to full-scale implementation of this new guidance, in order to avoid jeopardising supplies to those already receiving Rybelsus treatment
This is not about prohibition
