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Because of lack of sensitivity and problems with non-specificity of commercially available GLP-1R antisera detected multiple nonspecific immunoreactive proteins even in tissue extracts from Glp1r -/- mice
Conditionally essential means that the typical amount produced by the body is sufficient to meet its physiological requirement
Our group, working with partially deficient IGF-1 mice, has demonstrated that the liver is capable of expressing IGF-1R (which under physiological conditions it does not [99]) as a defence mechanism (peer review)
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That doesn't make compounded GLP-1 medications categorically unsafe
No treatment works like that
