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Inhibition of the glycolytic key enzyme LDHA or use of LDH inhibitors (such as sodium oxalate) can enhance CD8 + T cell killing ability, reverse tumor immune escape, and produce a synergistic effect with anti-PD-1 therapy

2014;9(2):e88862

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The results showed that the treatment with Ru(II)-OH reduced the tumor volume by 35%, the treatment with NP2 by 66%, and the treatment with NP4 by 91% (Fig