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Gatenby and Frieden, 2017)

Low Vitamin B12 levels may be related to dietary patterns, age-related absorption changes, digestive conditions, certain medications, autoimmune conditions such as pernicious anemia, or limited intake of animal-based foods

This is to ensure rapid replenishment of body stores to prevent irreversible consequences of deficiency

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Thus, Annexin V + 7-AAD cells represent apoptotic populations, while Annexin V + 7-AAD + cells reflect lytic cell death including pyroptotic death (Fig

Moreover, excessive alcohol intake can lead to a depletion of glutathione levels, resulting in an imbalance between reactive oxygen species and antioxidants, increasing oxidative stress, and causing damage to the liver