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In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected
Vitamin B12 is found in meat, fish, eggs, dairy products, yeast extract (such as Marmite) and specially fortified foods
B12 shots are also good for those getting treatments that might harm nerves, like chemotherapy
Laboratories using the compound in time-course or dose-response work should prepare fresh aliquots where possible, recording reconstitution date and storage temperature alongside each experimental block
After adding bacteriostatic water, gently swirl or roll the vial until the lyophilized powder has fully dissolved
While its still early in human research, the pathways it targets are well-documented in metabolic science, and the results so far are promising
