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One study found that weekly treatment with semaglutide, a GLP-1 RA, reduced the risk of a combination of stroke, heart attack, and death from cardiovascular causes by 20% compared with placebo.

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Common Side Effects and How to Manage Them Gastrointestinal effects including nausea, vomiting, and diarrhoea are the most common side effects, typically peaking during dose escalation and improving with smaller meals, adequate hydration, and avoidance of high-fat foods

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The key is identifying which mechanisms are operative in your case and intervening appropriately