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This is the first evidence that activation of HGF/MET signaling directly improves recovery of cognitive function after TBI, the effects of HGF treatment in preclinical models of neurodegenerative models 17,27,39,40 and spinal cord injury (SCI) 41,42 have been well studied
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The evidence In the CVOTs of empagliflozin, canagliflozin and dapagliflozin, significant benefit was demonstrated in a secondary composite renal endpoint compared to placebo (Wanner et al, 2016
It was also reported that unlike the inhibitory effects of propofol, sevoflurane preserved the mitochondrial respiratory chain function in a myocardial ischemic model (Lotz et al
GLP-1 has been tested as a regulator of anxiety behavior and both GLP-1 and exendin-4 (administered ip , into the lateral ventricle or intra-dorsal raphe) induced anxiety-like behavior, which was measured in the black and white box, elevated plus maze and open field tests in Spraque-Dawley rats [86]
