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The absence of Pin1 has been associated with age-dependent tau hyperphosphorylation and neurodegeneration [126]

Recent studies on Long COVID and ME/CFS patients have revealed signs of elevated oxidative stress and aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase, and lipid oxidative damage

It plays a crucial role in detoxification, cellular repair, and immune system function

Aging Clin

Curcumin has anti-inflammatory and antioxidant effects along with antiviral, antifungal, and clearing amyloid proteins (considered a major factor in Alzheimers Disease)

And as we're seeing the influence of these big trials, this is why many cardiology guidelines are now considering GLP ones in high risk patients