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A larger clinical trial randomly assigned more than 500 patients with type 2 diabetes and symptomatic peripheral neuropathy to one of the following treatments: (i) 600 mg/day of intravenous lipoic acid for three weeks followed by 1,800 mg/day of oral lipoic acid for six months, (ii) 600 mg/day of intravenous lipoic acid for three weeks followed by oral placebo for six months, or (iii) intravenous placebo for three weeks followed by oral placebo for six months (76)
In the case of humans and other mammals active during the day, the lower concentrations coincide with the period of greatest activity
its the most stable form of B12 and, unlike other forms of oral supplemental B12, its been studied rigorously
This is particularly relevant because so many injuries (chronic Achilles tendinopathy, rotator cuff tears) occur in areas with inherently limited blood flow
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References: Bailes J, Soloviev M
