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In one study, NO release limited bacterial virulence, and bacterial resistance to NO has not been reported to date [145]

344,345 Moreover, prodrug conjugates with microbially cleavable linkers may enable site-specific drug release in tumor regions devoid of resistance-conferring microbes

CrossRef Postprandial Increase in Energy Expenditure Correlates with Body Weight Reduction in Patients with Type 2 Diabetes Receiving Diet Therapy Daisuke Sanoyama, Mototsugu Nagao, Akira Asai, Yuko Nakamura, Kazumi Sato, Yasushi Nakajima, Shinichi Oikawa, Hitoshi Sugihara Journal of Atherosclerosis and Thrombosis.2017

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3.10 Research gaps and future directions Despite the availability of several potential protective strategies, substantial gaps remain in the understanding and management of imatinib-induced gonadotoxicity