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Chronic oxidative stress in the brainstem and peripheral nerves keeps the autonomic nervous system locked in a state of sympathetic dominance (the "fight-or-flight" response)
Other potential adverse effects of high dose and long-term glutathione supplementation include: Lightening of hair colour: A logically expected effect since hair colour is dependent on the amount and type of melanin which may be altered by glutathione supplementation
The most commonly tested forms of GSH supplements include reduced GSH and liposomal GSH
(2009) 4:e6413
Five-times-weekly dosing (weekdays on, weekends off) reduces total usage by about 30% while maintaining most benefits
B12 injections can begin working within hours or a few days
