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National Library of Medicine

The NHS notes that taking up to 2,000 micrograms daily is unlikely to cause harm in most people, though there is generally no benefit to such excessive amounts without confirmed deficiency

But a huge number of meat eaters are also deficient and likely dont know it B12 is absorbed through the stomach, and our ability to assimilate it through the stomach wall decreases with age, as well as due to any stomach issues like IBS, Crohns, and Celiac Disease, and medications that impact the stomach like metformin, antacids, PPIs, and ibuprofen

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Distribution: Transcobalamin II appears to be involved in the rapid transport of the cobalamin to tissues

Treatment is typically prescribed according to the underlying cause