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Like Modernas updated Spikevax and Pfizer/BioNTechs updated Comirnaty, Novavaxs vaccine corresponds to the Omicron variant JN.1 strain of SARS-CoV-2 and more closely targets the currently circulating variants, helping to prevent hospitalizations and death, according to the FDAs announcement

Cell Metabolism 2015

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The lack of uniform dosing schedules, varied patient groups, and small sample numbers in many trials makes it difficult to draw definitive conclusions from them [39]

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The diversity of circulating mediators suggests dynamic cross-talk among them, potentially leading to mutual stimulation or inhibition [61,64,67,119]