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GSL2 is a mitochondrial aminotransferase and a direct transcriptional target of P53, which binds to the corresponding element in the GLS2 gene and induces transcription of GLS2, which inhibits ferroptosis by increasing cellular antioxidant capacity by promoting the production of GSH and NADPH (39, 40), but has no direct effect on GPX4 expression through binding the GPX4 promoter (41)
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For instance, semaglutide has been approved and is being researched for indications including obesity, T2DM, reducing cardiovascular risk, chronic kidney disease, NAFLD, and AD, indicating that the development of new indications could provide new growth opportunities for GLP-1 drugs
Combining glutathione and niacinamide, it effectively fights the signs of aging and leaves skin smoother, softer, and more radiant
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