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patients had CKD stages 1 to 5 diagnosed by Kidney Disease: Improving Global Outcomes guidelines plus at least 3 months of one of the following: moderate to severe albuminuria regardless of estimated glomerular filtration rate (eGFR), eGFR less than 90 mL/min/1.73 m 2 with structural abnormalities of the kidney or urinary sediment abnormalities, or eGFR less than 60 mL/min/1.73 m 2 Efficacy End Points: Reduction in all-cause death, major adverse cardiovascular events (composite outcomes), and cardiovascular death
Community approach Shorter cycle Reported duration 4-6 weeks Reported break 2-4 weeks Evidence level Common research-community pattern
As typical for retrospective chart reviews, the outcome variables were limited to those that were systemically recorded on the patient charts during routine clinical outpatient visits, resulting in that some tests ( e.g
There is also the risk of long-term bone density loss, possibly resulting in fractured bones
